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. 2015 Jun 4;10(6):e0128870. doi: 10.1371/journal.pone.0128870

Table 3. Multivariable linear regression analysis of 10 Years Risk of CHD (Ln transformed) with serum Na+ and Glucose as predictor variables (ARIC Study).

Predictive capability of independent variables Analysis of variance
Dependent variable:Ln(10 Years Risk of CHD) Na+, mmol/l Glucose, mmol/l
Intercept Coefficient t P Coefficient t P F P
All participants (N = 12779) -1.86 0.017 4.2 <0.001 0.165 34.5 <0.001 598 <0.001
*No BP Medications (N = 10336) -2.50 0.020 4.2 <0.001 0.176 29.4 <0.001 432 <0.001
BP Medications (N = 3319) 0.29 0.009 1.6 n.s. 0.082 16.4 <0.001 138 <0.001
*Glucose < 6.5 mmol/l (N = 9360) -3.67 0.012 2.4 0.02 0.61 25.0 <0.001 319 <0.001
*White Men (N = 3788) -0.25 0.012 2.9 0.004 0.14 20.1 <0.001 202 <0.001
Women (N = 4453) -7.84 0.051 8.6 <0.001 0.23 24.8 <0.001 328 <0.001
*Black Men (N = 896) 0.23 0.007 0.9 n.s. 0.09 12.8 <0.001 86 <0.001
Women (N = 1199) -4.14 0.027 2.7 0.006 0.15 17.0 <0.001 145 <0.001

Serum Na+ and glucose are significant predictors of the 10 Years Risk of CHD when all study participants are included in analysis and in the following subsets: people who do not take blood pressure medications, people with blood glucose concentration lower than 6.5 mmol/l, white men, white women and black men.

* Participants who took blood pressure medications were excluded from the analysis