Gogtay 2006

Methods	Randomized (computer-generated) to PQ or bulaquine (1:2 ratio) after primary treatment with quinine + doxycycline
Participants	93 participants in India Inclusion criteria: 1. = 16 years 2. Male 3. Uncomplicated Pf only 4. = 55 P. falciparum gametocytes/μL on admission Exclusion criteria: 1. Antimalarial treatment in previous two weeks 2. Allergy to trial drug 3. G6PD deficient
Interventions	All patients: Quinine days 1 to 7: 30 mg/kg/day (10 mg/kg/day three times per day) + 100 mg doxycycline Randomization and treatment on day 4 1. PQ 2. Bulaquine
Outcomes	Gametocyte prevalence, density and viability on days 1, 4, 15, 22 and 29 Adverse events
Notes	Gametocyte viability assessed by Shute's technique (exflagellation)
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Low risk	Computer-generated randomization.
Allocation concealment (selection bias)	Unclear risk	Not reported.
Incomplete outcome data (attrition bias) All outcomes	Low risk	No evidence of incomplete data. Three participants (two bulaquine, one PQ) did not return for follow-up.
Selective reporting (reporting bias)	Low risk	No evidence of selective reporting.
Other bias	Low risk	None noted.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported.
Blinding of outcome assessment (detection bias) All outcomes	Low risk	Slide readers were blinded.