Khoo 1981

Methods	Individually RCT Dates of trial: between June 1976 and March 1978.
Participants	69 people (adults and children of both sexes, no ages specified) with G6PD deficiency (full or partial by Brewer's methaemoglobin reduction test) who were slide positive for malaria (P. falciparum, P. vivax or mixed). Site: Sabah, Malaysia. Exclusion criteria: other associated clinical conditions.
Interventions	1. CQ: 1.5 g CQ over 3 days for P. falciparum, P. vivax or mixed, less for children 2. CQ + PQ: CQ as above plus 75 mg PQ over 3 days for P. falciparum; 210 mg PQ over 14 days for P. vivax and mixed infections; less for children 3. SP (not included in this review): 1.5 g S and 75 mg P, single dose
Outcomes	1. Haemolysis 2. Proportion cleared parasites by 72 hours 3. Need for blood transfusion 4. Renal failure
Notes	The participants are not divided by P. falciparum, P. vivax or mixed, so it is not possible to use the data.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	"those found G6PD deficient were randomly assigned".
Allocation concealment (selection bias)	Unclear risk	No information given.
Incomplete outcome data (attrition bias) All outcomes	Unclear risk	No information given.
Selective reporting (reporting bias)	Low risk	No apparent selective reporting.
Other bias	Low risk	No indication of other bias.
Blinding of participants and personnel (performance bias) All outcomes	Unclear risk	Not reported.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	Not reported.