Chen 1993a

Methods	RCT
Participants	18 participants with P. falciparum
Interventions	A: MQ 750 mg B: MQ 750 mg + SP (1500 mg/75 mg) C: MQ 750 mg + PQ 45 mg All single doses Follow-up: 28 days for gametocytes and 21 days for infectiousness
Outcomes	Gametocyte prevalence at days 3, 8, 14, and 21 Infectiousness to An. dirus Sporozoite infections in mosquitoes Infectivity of sporozoite-infected mosquitoes to subsequent patients
Notes	Only abstract available. Mosquitoes fed on the patients were allowed to develop sporozoites which were then fed on uninfected people. One of the MQ + PQ group passed the infection to a new person.
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	Trial authors stated it was randomized in abstract.
Allocation concealment (selection bias)	Unclear risk	No information in abstract.
Incomplete outcome data (attrition bias) All outcomes	Low risk	All patients were followed up.
Selective reporting (reporting bias)	Unclear risk	No information in abstract.
Other bias	Unclear risk	None known.
Blinding of participants and personnel (performance bias) All outcomes	Low risk	Stated to be double blind in title.
Blinding of outcome assessment (detection bias) All outcomes	Unclear risk	No information in abstract.