Figure 2.
High fat feeding of adult C57BL/6J females for 4 months promotes oxidative stress. (A) F2-isoprostanes measured in liver. Circles represent values generated from individual animals, horizontal lines indicate mean values for each group and p value is given for t-test comparing diet group. (B) 4-HNE adducts measured in liver and adipose. (C) Superoxide dismutase and glutathione peroxidase activity in tissue muscle and adipose homogenates. (D) Plasma IL-6 and TNFα levels after 10 months high fat feeding. For B-D, bars indicate mean values ± SEM for mice fed chow (filled) or high fat (open) diets with asterisks representing p < 0.05 for t-test. For A-C, n=4/group; For D, n=5–18/group.