Figure 5.
Rotarod performance is altered by diet and age. (A) Average rotarod performance for chow (dark) and high fat fed (light) mice 4 months after diet started. p-value given is the result of Log-Rank test comparing the length of time each group remained on rod. (B) Correlation between body weight and time maintained on rotarod. Open (high fat) and closed (chow) circles indicate individual animals with trend-line given. R2 and p value are calculated for Spearman’s correlation. (C) Difference in latency to fall from rod between 4 month and 10 month time-points after starting high fat diet. Circles represent mean values ± SEM for n=15 chow (filled) or n=40 high fat (open) fed mice with asterisks representing p < 0.05 for t-test.