Table 3.
Residual tumor growth following indicated treatments and the CSC frequency estimated in re-implantation assays in NOD-SCID mice
Treatment | Number of Cells | Tumors/ Implantations |
CSC Frequency |
---|---|---|---|
Control | 1000 | 3/3 | 23 |
Control | 500 | 3/3 | |
Control | 100 | 3/3 | |
GSI | 1000 | 2/3 | 504 |
GSI | 500 | 0/3 | |
GSI | 100 | 1/3 | |
Docetaxel | 1000 | 3/3 | 88 |
Docetaxel | 500 | 2/3 | |
Docetaxel | 100 | 2/3 | |
GSI+Docetaxel | 1000 | 0/3 | 1602 |
GSI+Docetaxel | 500 | 0/3 | |
GSI+Docetaxel | 100 | 0/3 |
Group 1 | Group 2 | P value |
Control | Docetaxel | 0.219 |
Control | GSI | 0.000231 |
Control | GSI+Docetaxel | 1.21E-06 |
Docetaxel | GSI | 0.00543 |
Docetaxel | GSI+Docetaxel | 4.25E-05 |
GSI | GSI+Docetaxel | 0.0813 |