Improvement of indicator metabolite ratios and correlations between plasma metabolites and cardiac performance (left ventricle ejection fraction [LVEF]) after cardiac resynchronization therapy (CRT). A, Changes in indicator metabolite ratios in HF pre-CRT and HF post-CRT. B, A panel of metabolites that correlate positively and negatively with LVEF in HF pre-CRT group (*P<.05; ** P<.001). C, A panel of metabolites that correlate positively and negatively with LVEF in HF post-CRT group (*P<.05; ** P<.001). D, A panel of metabolites that correlate positively and negatively with delta LVEF in HF post-CRT group (*P<.05). Cit/Glut indicates citrate/glutamate; Glu/Palm, glucose/palmitate; Glutin/Glut, glutamine/glutamate; HF, heart failure; Succ/Glut, succinate/glutamate.