Figure 4.

Covariance analysis of the DHX29-bound 43S Pre-initiation complex (Hashem, et al., 2013). Two covariance maps are shown superimposed with the whole complex. (a) and (b), segmented density map of the DHX29-bound 43S Preinitiation complex. (C) and (d), overlays of covariance maps corresponding to two reference voxels chosen in DHX29 and an unassigned peripheral subunit of eIF3, respectively, showing the DHX29 protein in its entirety (green mesh) and the unassigned peripheral subunit of eIF3 (gray arrow on purple mesh). The latter exhibits positive correlation with parts of DHX29, as demonstrated by the overlapping regions with the map of DHX29. See text.