Skip to main content
. Author manuscript; available in PMC: 2016 Jun 1.
Published in final edited form as: JAMA Psychiatry. 2015 Jun 1;72(6):603–611. doi: 10.1001/jamapsychiatry.2015.0071

Figure 1. Results of meta-analysis.

Figure 1

Seed regions-of-interest categorized by a priori functional network (left panels), and results of meta-analysis (right panels) showing regions in which abnormal resting-state functional connectivity (rsFC) was observed in individuals with Major Depressive Disorder (MDD) as compared to healthy controls (HC). (A) MDD individuals exhibited hypoconnectivity within the frontoparietal network (FN), between FN seeds and posterior parietal cortex (PPC); and hypoconnectivity between FN seeds and a region of superior parietal lobule (SPL) within the dorsal attention network (DAN). (B) MDD was associated with hyperconnectivity within the default network (DN), between DN seeds and medial prefrontal cortex (MPFC) and hippocampus; and hyperconnectivity between DN seeds and dorsolateral prefrontal cortex (DLPFC), a key hub of FN. (C) MDD was linked to hypoconnectivity between seeds in the affective network (AN) and regions of MPFC. (D) MDD was related to hypoconnectivity between VAN seeds and precuneus extending to occipital and posterior cingulate cortex (PCC), although post-hoc analyses also indicated hyperconnectivity between VAN and posterior regions. Shown here are results of both height-based (hb) thresholding (proportion of studies reporting an effect at that voxel exceeds chance) and extent-based (eb) thresholding (proportion of studies reporting an effect at contiguous voxels exceeds chance), all results significant at p<0.05, corrected for Family-Wise Error-Rate.