Table 1.

Results of meta-analysis of resting-state functional connectivity in Major Depressive Disorder.

Seed network (and thresholding)	Seed anatomy	Effect network	Effect anatomy	X	Y	Z	Voxels	max P
FN	caudate, cerebellum, DLPFC
MDD < HC (hb)		FN	r. PPC	44	−50	50	162	0.54
MDD < HC (eb)		FN/DAN	r. PPC/ SPL	46	−54	46	2074	0.40
MDD < HC (eb)		FN/DAN	l. PPC/ SPL	−42	−52	48	2285	0.34
DN	ACC, caudate, cerebellum, hippocampus, IPL, MPFC, MTG, PCC
MDD > HC (hb)		DN	r. hippocampus/ MTG	38	−30	−6	148	0.30
MDD > HC (eb)		DN	MPFC	−2	38	12	7456	0.20
MDD > HC (hb)		FN	l. DLPFC	−42	26	32	90	0.30
MDD > HC (eb)		FN	l. DLPFC	−38	26	36	784	0.29
MDD > HC (eb)		FN	l. DLPFC	−34	34	36	1125	0.18
MDD < HC (eb)		VAN	mid-cingulate/ thalamus/ putamen	−2	4	22	2476	0.26
AN	ACC, amygdala, NACC
MDD < HC (eb)		DN	MPFC	−2	46	16	3118	0.37
VAN
MDD < HC (eb)	ACC,cerebellum, insula, putamen	FN/DN/Vis	precuneus/ PCC/ occipital cortex	18	−66	34	6194	0.32

Note: Results of comparison between individuals with Major Depressive Disorder (MDD) and healthy controls (HC). Thresholding was height-based (hb) or extent-based (eb) corrected to p<0.05; seed or effect networks included affective network (AN), dorsal attention network (DAN), default network (DN), frontoparietal network (FN), ventral attention network (VAN), or visual network (Vis); anatomical regions included anterior cingulate cortex (ACC), amygdala, caudate, cerebellum, dorsolateral prefrontal cortex (DLPFC), hippocampus, inferior parietal cortex (IPL), insula, medial prefrontal cortex (MPFC), middle temporal gyrus (MTG), nucleus accumbens (NACC), occipital cortex, posterior cingulate cortex (PCC), posterior parietal cortex (PPC), precuneus, putamen, superior parietal lobule (SPL), and thalamus. Coordinates are MNI standard stereotaxic space; Voxels = number of 1×1×1mm voxels; max P = maximum proportion of studies exhibiting the effect at the peak density, weighted by sample size.