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. 2015 Jun 4;11(6):e1004825. doi: 10.1371/journal.ppat.1004825

Fig 1. Replication cycle of poliovirus, annotated with references to key findings during the past 65 years.

Fig 1

Abbreviations and symbols: 3D, three-dimensional; receptor proteins (grey cylinders spanning plasma membrane); RNA, ribonucleic acid; VPg, viral protein, genome-linked (red oval); ribosomes (medium blue oval shapes bound to viral RNA); + strand RNA, positive-sense genomic RNA (blue horizontal or wavy line);—strand RNA, negative-sense antigenomic RNA (red horizontal or wavy line); 3Dpol, viral RNA-dependent RNA polymerase (pink shapes); membranous vesicles (light blue oval shapes); Nups, nucleoporins (orange, oblong oval shapes).