Table 3. Univariate logistic regression model associations between KRAS mutation status and MMR status.
| pMMR-Mutant KRAS | dMMR-Mutant KRAS | |||
|---|---|---|---|---|
| Characteristics | OR (95% CI) | P | OR (95% CI) | P |
| Female (referent: male) | 1.85 (1.39 to 2.46) | <0.0001 | 0.56 (0.20 to 1.57) | 0.37 |
| Proximal (referent: distal) | 2.00 (1.30 to 3.08) | 0.002 | 1.63 (0.48 to 5.50) | 0.43 |
| Proximal (referent: Rectum) | 1.31 (0.89 to 1.93) | 0.17 | 0.54 (0.10 to 3.02) | 0.76 |
| pT 3–4 (referent: pT 1–2) | 1.14 (0.75 to 1.72) | 0.54 | 0.27 (0.06 to 1.19) | 0.15 |
| pN 1–2 (referent: pN 0) | 1.48 (1.11 to 1.96) | 0.007 | 0.67 (0.24 to 1.82) | 0.43 |
| Low grade (referent: moderate to high grade) | 0.81 (0.56 to 1.18) | 0.28 | 0.51 (0.18 to 1.48) | 0.22 |
| Mucinous (referent: non-mucinous) | 1.50 (1.11 to 2.01) | 0.007 | 1.61 (0.58 to 4.53) | 0.36 |
| pTNM III–IV (referent: pTNM I–II) | 1.38 (1.04 to 1.83) | 0.03 | 0.78 (0.29 to 2.11) | 0.63 |
| Age ≥ 50 years (referent: < 50 years) | 1.38 (0.98 to 1.94) | 0.06 | 0.63 (0.23 to 1.69) | 0.35 |
| Tumor size < 6cm (referent: ≥ 6cm) | 1.09 (0.78 to 1.54) | 0.61 | 0.71 (0.26 to 1.92) | 0.50 |
CI = confidence interval; dMMR = deficient mismatch repair; pMMR = proficient mismatch repair; OR = odds ratio.
‡ = Two-sided χ2 test with continuity correction
§ Fischer’s exact test
Others are two-sided χ2 test.
A P value for significance was adjusted for multiple hypothesis testing to P = 0.05/6 = 0.0083. Thus, a P value between 0.05 and 0.0083 should be regarded as of borderline significance.