Table 1.
PTPN11 mutations associated with leukemia patients from the phase III clinical trial run by ECOG E1900 (47).
| PTPN11 mutation details | Consensus Cytogenetic Risk | dfs | efs status | efs | os status | ||
|---|---|---|---|---|---|---|---|
| Genomic coordinates | Nucleotide change | AA change | |||||
| 12:112888211 | A/G | E76G | Intermediate I | 1205 | 1 | 1244 | 1 |
| 12:112888202 | C/T | T73I | Indeterminate | 352 | 1 | 385 | 1 |
| 12:112888210 | G/C | E76Q | Intermediate II | 1 | 0 | 1 | |
| 12:112888165 | G/T | D61Y | Favorable | 2114 | 0 | 2172 | 0 |
| 12:112888197 | T/G | F71L | Indeterminate | 1401 | 0 | 1429 | 0 |
| 12:112888211 | A/G | E76G | Unfavorable | 56 | 1 | 82 | 1 |