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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2015 Mar 16;4(4):377–389. doi: 10.1002/wdev.185

Figure 4. GDNF modulates Sema3B responsiveness by regulating PlexA1 proteolysis.

Figure 4

As spinal commissural axons are growing toward the midline, calpain cleaves the Sema3B receptor PlexA1 to reduce sensitivity to Sema3B. When these neurons reach the midline, GDNF signals through NCAM and its co-receptor GFRα1 to reduce calpain activity. Sema3B then signals repulsion through Nrp2 and PlexA1.