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. Author manuscript; available in PMC: 2016 Jul 1.
Published in final edited form as: Wiley Interdiscip Rev Dev Biol. 2015 Mar 16;4(4):377–389. doi: 10.1002/wdev.185

Figure 5. Comm regulates Slit responsiveness by inhibiting trafficking of Robo to the growth cone.

Figure 5

In Drosophila, as commissural neurons grow toward the midline, they express the endosomal protein Comm, which targets newly synthesized Robo for lysosomal degradation. Fra regulates comm transcription independent of its canonical ligands, Netrins. After crossing, Comm expression is extinguished and Robo is trafficked to the growth cone, where it signals repulsion in response to Slit.