Fig 8. Effects of AP-12 (1mg/kg) on spatial memory in Tg APP_SweDI mice (n = 8 mice/group) in water maze test.

The compound was injected once a day for 17 days. (A) Two line graphs showing the learning curves of the two groups of mice. Daily mean latency calculated from four trials. Values are mean ± SEM. Significance was measured by two-way ANOVA followed by Bonferroni Multiple Comparison post-test. *p<0.05 vs. saline control group. (B) The probe trial test.