Table 2. LOH of major tumor suppressor genes in each histology.
| Gene | TP53 | NF1 | BRCA1 | RB1 | BRCA2 | |
|---|---|---|---|---|---|---|
| Chr | 17 | 17 | 17 | 13 | 13 | |
| Cytoband | 17p13.1 | 17q11.2 | 17q21.2 | 13q14.2 | 13q13.2 | |
| n = 13 | SC-1 | LOH | LOH | LOH | LOH | LOH |
| SC-2 | LOH | LOH | LOH | LOH | LOH | |
| SC-3 | LOH | LOH | LOH | LOH | LOH | |
| SC-4 | LOH | LOH | LOH | LOH | LOH | |
| SC-5 | LOH | LOH | LOH | LOH | LOH | |
| SC-6 | LOH | LOH | LOH | LOH | LOH | |
| SC-7 | CNN LOH | LOH | LOH | LOH | LOH | |
| SC-8 | CNN LOH | CNN LOH | CNN LOH | LOH | LOH | |
| SC-9 | LOH | LOH | LOH | nl | nl | |
| SC-10 | LOH | CNN LOH | LOH | nl | nl | |
| SC-11 | CNN LOH | LOH | LOH | nl | nl | |
| SC-12 | CNN LOH | nl | nl | nl | nl | |
| SC-13 | nl | nl | nl | nl | nl | |
| n = 31 | CCC-1 | LOH | nl | nl | LOH | LOH |
| CCC-2 | LOH | nl | nl | LOH | LOH | |
| CCC-3 | LOH | nl | nl | LOH | nl | |
| CCC-4 | LOH | nl | nl | nl | nl | |
| CCC-5 | LOH | nl | nl | nl | nl | |
| CCC-6 | LOH | nl | nl | nl | nl | |
| CCC-7 | nl | nl | nl | LOH | LOH | |
| CCC-8 | nl | nl | nl | CNN LOH | CNN LOH | |
| Other 23 cases (CCC 9–31) | nl | nl | nl | nl | nl | |
| n = 13 | EC-1 | LOH | LOH | LOH | CNN LOH | LOH |
| EC-2 | LOH | nl | nl | nl | nl | |
| EC-3 | LOH | nl | LOH | nl | nl | |
| EC-4 | CNN LOH | LOH | CNN LOH | LOH | nl | |
| EC-5 | CNN LOH | LOH | LOH | nl | nl | |
| Other 8 cases (EC6-13) | nl | nl | nl | nl | nl |
nl: no copy number alterations, CNN LOH: Copy number neutral loss of heterozygosity.