Fig. 3.

Similarities between early RPE maturation and healing processes. (a) Differentiation and morphology changes: case and control cell lines changed their morphology from a fibroblastic-like to a cuboidal shape during the differentiation and maturation stage. This was accompanied by an increase in measurement fluctuations. The resistance decreased when the epithelial stage was reached which was attributed to the change in cell size and morphology. (b) Wounding and morphology changes: unwounded cells changed morphology from cuboidal to elongated in order to migrate and repopulate the electrodes. The reverse process then occurred after closing the wound. (c) Moving Variance showed a clear transition phase associated with a transition from an elongated to a cuboidal morphology.