TABLE 1.

Downregulated miRNAs (<0.5-fold change) in skeletal muscles of a dbTg1 mouse (n = 1) compared with those in a WT mouse (n = 1)

miRNAb	Fold change	Tissue distribution	Target(s) in skeletal musclea	Reference(s)
mmu-miR-29c*	0.21	Unclear	Unclear
mmu-miR-193	0.28	Brown adipose tissue	Cdon, Igfbp5	58
mmu-miR-193b	0.37
mmu-miR-378	0.32	Muscle	MyoR, IGF1R	47, 59
mmu-miR-29c	0.32	Ubiquitous	YY1	60, 61
mmu-miR-3107	0.32	Unclear	Unclear
mmu-miR-185	0.33	Unclear	Unclear
mmu-miR-365	0.33	Brown adipose tissue	Unclear	58
mmu-miR-136	0.40	Unclear	Unclear
mmu-miR-30a*	0.42	Unclear	Unclear
mmu-miR-133a*	0.42	Unclear	Unclear
mmu-miR-133a	0.43	Muscle	SRF, nPTB, UCP2	46, 62, 63
mmu-miR-133b	0.47
mmu-miR-196a	0.44	Unclear	Unclear
mmu-miR-30a	0.44	Ubiquitous	Snai1	64–66
mmu-miR-30c	0.45
mmu-miR-345-5p	0.45	Unclear	Unclear
mmu-miR-30e*	0.46	Unclear	Unclear
mmu-miR-151-5p	0.47	Unclear	PLM	67
mmu-miR-101b	0.48	Unclear	Unclear
mmu-miR-378*	0.48	Unclear	Unclear
mmu-miR-1	0.49	Muscle	HDAC4, Cx43, Pax7, c-Met, G6PD	46, 52, 68–70
mmu-miR-361	0.49	Unclear	Unclear

^aIGF1R, insulin-like growth factor 1 receptor; SRF, serum response factor; HDAC4, histone deacetylase 4; G6PD, glucose-6-phosphate dehydrogenase.

^bAsterisks indicate the antisense form of miRNA.