FIG 1.

Decreased weight loss and pathology in IRF9-deficient animals upon 2% DSS treatment. (A) Representative weight loss curve (n = 4 mice/group); (B) representative H&E stainings from colons on day 10 of 2% DSS colitis (200-fold magnification) and pathology score data from 3 independent experiments (WT n = 19, Irf9^−/− n = 18). (C) Proliferation rates are increased in IRF9-deficient colons. Representative pictures (×200 magnification) and quantification of colon tissue of WT and Irf9^−/− mice after 5 days of 2% DSS treatment, stained for Ki67 (n = 10/group). Data are presented as means ± standard errors of the mean (SEM) and are representative of at least 3 independent experiments. *, P < 0.05; **, P < 0.01, Mann-Whitney U test.