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When a nucleosome is remodeled by ISW1a (left), nucleosome repositioning is blocked by a bound TF, the TF remains intact, and the remodeled nucleosome is positioned with the TF acting as a boundary and reference point. On the other hand, when a nucleosome is remodeled by SWI/SNF (right), nucleosome positioning is unaffected by a bound TF and the TF is evicted.
