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Proband's skeletal muscle cryostat sections. Muscle sections stained with (A) H&E or (B) modified Gomori trichrome stain demonstrate marked variability in fiber size, with fiber atrophy and fatty infiltration. Ragged red fibers are marked by arrows in both panels. (C) SDH/COX staining demonstrated several fibers (arrow) with SDH activity (blue) that lack COX activity (brown). Original magnifications: (A), 200X; (B,C), 400X.
