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. 2015 Jun 2;84(22):2247–2257. doi: 10.1212/WNL.0000000000001642

Figure 1. Summary of the cross-sectional analyses of NfL levels in the Oxford and London cohorts.

Figure 1

NfL levels (median [interquartile range]) in patients with amyotrophic lateral sclerosis and controls in the cross-sectional analysis using (A) CSF, (B) serum, and (C) plasma (Mann–Whitney U test). Results of receiver operating characteristic analysis are shown in the right panel. (D) Matched CSF and serum NfL levels are strongly correlated in controls and in patients with ALS. (E) Blood NfL levels are strongly correlated with progression rate at baseline in both London and Oxford cohorts. AUC = area under the curve; NfL = neurofilament light chain.