Table 4.

Estimated sample sizes with bootstrap 95% CIs to detect a 25% reduction in TBM-SyN with 80% power and two-sided α = 0.05

	Accelerated n (95% CI)	Unaccelerated n (95% CI)	Difference* n (95% CI)
Baseline to 3 months
CN	2238 (1089, 8984)	1729 (897, 4596)	509 (−751, 5349)
EMCI	2850 (1507, 7799)	2673 (1409, 7865)	177 (−3641, 2687)
LMCI	1015 (584, 2303)	841 (499, 1754)	174 (−373, 1068)
AD	593 (328, 1332)	438 (254, 1009)	155 (−103, 761)
Baseline to 6 months
CN	749 (446, 1524)	667 (421, 1332)	82 (−152, 446)
EMCI	1213 (728, 2532)	898 (580, 1605)	315 (−7, 1297)
LMCI	297 (213, 451)	286 (202, 428)	11 (−95, 132)
AD	133 (74, 271)	107 (70, 192)	26 (−50, 138)
Baseline to 12 months
CN	259 (181, 412)	276 (200, 404)	−17 (−84, 46)
EMCI	361 (265, 523)	272 (205, 375)	89 (35, 182)
LMCI	157 (113, 219)	154 (108, 230)	3 (−39, 36)
AD	56 (33, 97)	51 (30, 93)	5 (−25, 32)

^*Difference defined as the accelerated sample size minus the unaccelerated sample size.

Confidence intervals that exclude zero may be considered significant at α = 0.05.