Table 2.

The scores of efficacy endpoints at baseline, and at 2, 4, 8, and 12 week visits

Total		Baseline	At 2 week	At 4 week	At 8 week	At 12 week
Dry eye symptom score		14.5 ± 6.97	9.80 ± 5.26 ***	7.04 ± 5.42 ***	7.04 ± 6.46 ***	7.83 ± 6.82 ***
Fluorescein ocular surface staining score		3.0 (2.0–5.3)	2.0 (1.0–3.0)***	2.0 (1.0–4.0)***	1.0 (0.0–3.0)***	1.0 (0.0–3.0)***
	Fluorescein cornea staining score	1.0 (1.0–2.0)	1.0 (0.0–1.0)**	1.0 (0.3–1.0)*	1.0 (0.0–1.0)**	1.0 (0.0–1.0)***
	Fluorescein conjunctiva staining score	2.0 (1.0–3.0)	1.0 (0.0–2.0)**	1.0 (0.0–2.8)**	0.0 (0.0–2.0)**	1.0 (0.0–2.0)**
TBUT		2.5 (2.0–3.0)	3.0 (2.0–3.0)	3.0 (2.0–3.0)	3.0 (3.0–4.0)*	3.0 (2.0–3.3)
Schirmer’s test		6.0 (3.0–10.3)	7.5 (3.5–12.4)	9.0 (4.8–13.0)	7.0 (4.0–12.3)	6.5 (4.0–10.3)

Values are mean ± SD or median (IQR)

*P’ < 0.05, **P’ < 0.01, ***P’ < 0.001

P’ = corrected P value with Bonferroni method

† one sample paired t-test were performed in the analyses of only dry eye symptom score, and Wilcoxon signed-rank tests were performed in the analyses of any other items