Table 3.

The median scores of 11 parameters about dry eye related symptom at baseline, and at 2, 4, 8, and 12 week visits

Ocular symptom	Baseline	At 2 week	At 4 week	At 8 week	At 12 week
Foreign body sensation	1.5 (0.8–2.3)	1.0 (0.0–1.3)*	0.0 (0.0–1.0)**	0.0 (0.0–1.0)**	0.0 (0.0–1.0)**
Photophobia	2.0 (0.8–2.3)	1.5 (0.8–2.0)	1.0 (0.0–2.0)**	0.0 (0.0–1.0)**	0.5 (0.0–1.3)
Itching	0.0 (0.0–1.0)	0.0 (0.0–0.0)	0.0 (0.0–1.0)	0.0 (0.0–1.0)	0.0 (0.0–0.3)
Eye pain	1.0 (0.0–3.0)	1.0 (0.0–1.0)*	0.0 (0.0–1.0)*	0.0 (0.0–1.0)*	0.0 (0.0–1.0)
Dry eye sensation	2.5 (1.0–3.0)	1.0 (0.8–2.0)*	1.0 (0.0–1.5)**	1.0 (0.0–2.0)**	1.0 (0.0–2.3)**
Heaviness	1.0 (0.0–2.0)	0.0 (0.0–1.0)*	0.0 (0.0–0.5)*	0.0 (0.0–0.0)	0.5 (0.0–1.0)
Blurred vision	2.0 (0.0–2.0)	1.0 (0.0–2.0)	1.0 (0.0–2.0)	0.0 (0.0–2.0)	0.5 (0.0–2.0)
Asthenopia	2.0 (1.0–2.0)	1.0 (1.0–2.0)	1.0 (0.0–2.0)	1.0 (0.0–2.0)*	1.0 (0.0–2.0)*
Ocular discomfort	2.0 (0.8–3.0)	1.0 (0.0–2.0)*	1.0 (0.0–1.0)**	1.0 (0.0–1.5)**	0.0 (0.0–1.0)**
Eye discharge	0.5 (0.3–1.5)	0.0 (0.0–1.0)	0.0 (0.0–1.0)	0.0 (0.0–1.0)	0.0 (0.0–1.0)
Tearing	0.5 (0.0–0.3)	0.0 (0.0–0.0)	0.0 (0.0–0.5)	0.0 (0.0–0.0)	0.0 (0.0–0.0)

Values are median (IQR)

* P’ < 0.05, ** P’ < 0.01

P’ = corrected P value with Bonferroni method