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. 2015 May 10;16(1):373. doi: 10.1186/s12864-015-1527-z

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© Nault et al. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Comparison of RNA-Seq and Agilent dose–response modeling. (A) The ToxResponse modeler [36] was used to identify genes fitting a sigmoidal response for the estimation of ED₅₀s while (B) BMDExpress [35] was used to find the best fit curves for point of departure (BMD and BMDL) estimates. Correlation of (C) ED₅₀s and (D) BMD (blue circles) and BMDL (red circles) estimates were examined for all comparable genes.