Table 4.

Utility weights per health state

Health state	Derivation	Utility weight
Baseline	Based on average utilities of patients at baseline	0.848
Response	Value at Week 12	0.887
No response	Value at Week 12	0.870
Second-line treatment	Average of response and no response health states	0.879
Withdrawal	Assumed to be equal to the baseline utility	0.848
Discontinuation	Assumed to be equal to the baseline utility	0.848
Post-surgery	Derived by combining response utility value from NEPTUNE study with disutilities from [23], weighted by probability of improvement, no improvement and adverse events after surgery [23]	0.839
Death	Lowest utility possible	0.000