Table 2.
Summary of literature search - smoking addiction
| Author | Ethnicity | Sample size | Phenotype | Salient gene(s) | Salient SNP(s) | Statistical analysis |
|---|---|---|---|---|---|---|
| Agrawal et al. [96] | EA | 1929 | Nicotine dependence | GABRA4, GABRA2, GABRE | P = 0.030 | |
| Agrawal et al. [97] | EA | 1921 | Nicotine dependence | GABRA4, GABRA2 | P = 0.002 | |
| Anney et al. [98] | E | 815 | Cigarette dose | CHRM5 | rs7162140 | P = 0.01 |
| Baker et al. [31] | EA | 886 | Nicotine dependence | CHRNA5-A3-B4 | P = 0.04 | |
| Berrettini et al. [99] | EA | 1276 | Nicotine addiction | CYP2A6 | rs410514431 | P = 1.0E-12 |
| Beuten et al. [100] | EA, AA | 2037 | Nicotine dependence | BDNF | rs6484320 rs988748 rs2030324 rs7934165 | P = 0.002 |
| Beuten et al. [101] | EA, AA | Nicotine dependence | GABAB2 | rs2491397 rs2184026 rs3750344 rs1435252 rs378042 rs2779562 rs3750344 | P = 0.003 | |
| Beuten et al. [102] | EA, AA | Nicotine dependence | COMT | rs933271 rs4680 rs174699 | P = 0.0005 | |
| Broms et al. [32] | E | 1428 | Nicotine dependence | CHRNA5, CHRNA3, CHRNB4 | rs2036527 rs578776 rs11636753 rs11634351 rs1948 rs2036527 | P = 0.000009, 0.0001, 0.0059, 0.0069, 0.0071, 0.0003 |
| Chen et al. [103] | 688 | Nicotine dependence | CNR1 | rs2023239 rs12720071 rs806368 | P < 0.001 | |
| Chen et al. [79] | EA, AA | 3627 | Nicotine addiction | PKNOX2 | rs1426153 rs11220015 rs11602925 rs750338 rs12273605 rs10893365 rs10893366 rs12284594 | P = 0.0159, 0.0163, 0.0136, 0.0491, 0.0921, 0.0411, 0.0621, 0.0239 |
| Conlon et al. [33] | EA | 1122 | Nicotine dependence | CHRNA5, CHRNA3, AGPHD1 | rs16969968 rs578776 rs8034191 | OR = 3.2, 2.8, 0.3 |
| Culverhouse et al. [34] | AA, EA | 18500 | Nicotine dependence | CHRNB3, CHRNA7 | rs13273442 | P = 0.00058 for EA, 0.05 for AA |
| Docampo et al. [104] | E | 752 | Lower risk for smoking behavior | NRXN3 | rs1424850 rs221497 rs221473 | rs1424850: OR = 0.55, P = 0.0002 |
| rs221497: OR = 0.47, P = 0.0020 | ||||||
| rs221473: OR = 0.54, P = 0.0009 | ||||||
| Ehringer et al. [35] | EA, Hisp, AA | 108 | Nicotine response | CHRNB2 | rs2072658 | |
| Ella et al. [105] | Japanese | 2521 | Nicotine addiction | DBH | rs5320 | P = 0.030 |
| Gabrielsen et al. [36] | Norwegian | 155941 | Smoking status(cigarettes per day, duration, packs per year) | CHRNA5/A3/B4 | rs16969968 | P = 3.15E-25, 1.11E-6, 3.01E-23 (respectively for phenotypes) |
| Huang et al. [106] | EA, AA | 3403 | Nicotine dependence | ANKK1 | rs2734849 | P = 0.0026 |
| Lang et al. [107] | E | 320 | Smoking behavior | BDNF | P = 0.045 | |
| Li et al. [38] | EA, AA | 2037 | Nicotine dependence | CHRNA4 | rs2273504 rs1044396 rs3787137 rs2236196 | |
| Liu et al. [108] | EA, AA | 2091 | Smoking behavior | IL15 | rs4956302 | P = 8.8E-8 |
| Ma et al. [109] | EA, AA | 2037 | Nicotine dependence | DDC | rs3735273 rs1451371 rs3757472 rs3735273 rs1451371 rs2060762 | P = 0.005, 0.006 |
| Mobascher et al. [110] | German | 5500 | smoking behavior/nicotine addiction | CHRM2 | rs324650 | OR = 1.17 |
| Nees et al. [39] | E, EA | 965 | Nicotine dependence | CHRNA5/A3/B4 | rs578776 | P < 0.05 |
| Sherva et al. [40] | EA, AA | 435 | Smoking | CHRNA5 | rs16969968 | P = 0.0001 |
| Rice et al. [29] | EA, AA | 3365 | Nicotine dependence | CHRNB3 | rs1451240 | P = 2.4E-8 |
| Sarginson et al. [30] | EA, Asian, AA, Hispanic | 577 | Smoking behavior | CHRNA5/A3/B4 | rs16969968 rs1051730 | P < 0.0001 |
| Sorice et al. [41] | E | 2272 | Smoking behavior | CHRNA5-A3-B4 | rs1051730 | P = 0.0151, 0.022, 0.22 for three populations |
| Voisey et al. [52] | EA | 378 | Nicotine dependence | DRD2 | rs1800497 | P = 0.0003 |
| Wang et al. [43] | EA, AA | 3622 | ND (smoking quantity and FTND) | CHRNA2, CHRNA6 | EA: rs3735757 rs2472553 | EA: P = 0.0068 for FTND, AA: P = 0.0043 for SQ and 0.00086 for FTND |
| Wassenaar et al. [44] | E | 860 | Nicotine dependence | CYP2A6 and CHRNA5-A3-B4 | rs1051730 | P =0.036 |
| Weiss et al. [45] | E | 2827 | Nicotine dependence | CHRNA5-A3-B4 | rs17486278 | P = 0.0005 |
| Zeiger et al. [46] | EA, Hisp | 1056 | Response to smoking | CHRNA6, CHRNB3 | rs4950 rs13280604 rs2304297 | P = 0.043, 0.011, 0.053 |