Table 4.
Overlapping genes for networks of nicotine, alcohol and opioid addiction; focus genes from literature are bolded
| A: Opioids ∩ Alcohol | B: Opioids ∩ Nicotine | C: Opioids ∩ Alcohol ∩ Nicotine | |||
|---|---|---|---|---|---|
| Molecule | Edges in opioid network/edges in alcohol network | Molecule | Edges in opioid network/edges in nicotine network | Molecule | Edges in opioid network/edges in alcohol network/edges in nicotine network |
| NFkB (complex) | 112/86 | ERK1/2 | 74/76 | ERK1/2 | 74/62/76 |
| ERK1/2 | 74/62 | ARRB2 | 8/3 | DRD2 | 6/3/4 |
| IL1R1 | 7/4 | DRD2 | 6/4 | TAP1 | 5/5/3 |
| IL1 | 6/8 | HSPD1 | 5/4 | SAA | 4/3/4 |
| DEFB4A/DEFB4B | 6/4 | TAP1 | 5/3 | PSMB9 | 4/3/3 |
| DRD2 | 6/3 | SAA | 4/4 | TAPBP | 4/3/3 |
| ELANE | 5/6 | PSMB9 | 4/3 | ELF3 | 4/3/2 |
| F2RL1 | 5/6 | TAPBP | 4/3 | TAC1 | 4/3/2 |
| TAP1 | 5/5 | ELF3 | 4/2 | CLEC11A | 3/4/2 |
| F2R | 5/3 | TAC1 | 4/2 | SMPD2 | 3/3/3 |
| ADRBK1 | 5/2 | PSMB10 | 3/3 | CXCL3 | 3/3/2 |
| Ikb | 4/4 | SMPD2 | 3/3 | P2RY6 | 3/3/2 |
| CXCL2 | 4/3 | AKAP13 | 3/2 | PSMB10 | 3/2/3 |
| ELF3 | 4/3 | CLEC11A | 3/2 | AKAP13 | 3/2/2 |
| FPR2 | 4/3 | CXCL3 | 3/2 | TLR6 | 3/2/2 |
| PSMB9 | 4/3 | P2RY6 | 3/2 | CRHR1 | 2/4/3 |
| SAA | 4/3 | TLR6 | 3/2 | CD244 | 2/3/3 |
| TAC1 | 4/3 | CD244 | 2/3 | CXCL5 | 2/3/2 |
| TAPBP | 4/3 | CRHR1 | 2/3 | CCL21 | 2/2/2 |
| DEFB103A/DEFB103B | 4/2 | CCL21 | 2/2 | GMFG | 2/2/2 |
| LTF | 3/5 | CNR1 | 2/2 | ||
| TNFSF11 | 3/5 | CXCL5 | 2/2 | ||
| TNFSF15 | 3/5 | GMFG | 2/2 | ||
| CLEC11A | 3/4 | GPRASP1 | 2/2 | ||
| TLR1 | 3/4 | BDNF | 2/1 | ||
| CXCL3 | 3/3 | ||||
| KLF6 | 3/3 | ||||
| P2RY6 | 3/3 | ||||
| SMPD2 | 3/3 | ||||
| AKAP13 | 3/2 | ||||
| ARF6 | 3/2 | ||||
| IER3 | 3/2 | ||||
| PSMB10 | 3/2 | ||||
| TLR6 | 3/2 | ||||
| TRPC6 | 3/2 | ||||
| CRHR1 | 2/4 | ||||
| CCL22 | 2/3 | ||||
| CD244 | 2/3 | ||||
| CXCL5 | 2/3 | ||||
| CC2D1A | 2/2 | ||||
| CCL21 | 2/2 | ||||
| GMFG | 2/2 | ||||
| SH3GLB2 | 2/2 | ||||
| STAB2 | 2/2 | ||||
| TSC22D3 | 2/2 | ||||
| OPRM1 | 1/2 | ||||