Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Pain
Systematic review	Children aged <17 years 5 RCTs in this analysis	Proportion of children with headache relief 2 hours 308/474 (65%) with nasal sumatriptan 254/493 (51%) with placebo	RR 1.26 95% CI 1.13 to 1.41 Several RCTs included in the meta-analysis had weak methods, which may have confounded results, including failure to report pre-crossover results, high withdrawal rates, and a protocol allowing use of rescue medications	Small effect size	sumatriptan
Systematic review	Children aged <17 years 4 RCTs in this analysis	Proportion of children who were pain free 2 hours 144/356 (40%) with nasal sumatriptan 94/362 (26%) with placebo	RR 1.56 95% CI 1.26 to 1.93 Several RCTs included in the meta-analysis had weak methods, which may have confounded results, including failure to report pre-crossover results, high withdrawal rates, and a protocol allowing use of rescue medications	Small effect size	sumatriptan