Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Taste disturbance
RCT 3-armed trial	Children aged 12–17 years In review	Taste disturbance 60/238 (25%) with nasal sumatriptan 20 mg 48/255 (19%) with nasal sumatriptan 5 mg 4/245 (2%) with placebo	Significance not assessed
RCT Crossover design	129 children, 94 included in the intention-to-treat analysis In review	Taste disturbance 26/90 (29%) attacks with nasal sumatriptan 3/87 (3%) attacks with placebo	P <0.001 The results of the RCT should be interpreted with caution as it randomised children but assessed results in relation to number of attacks	Effect size not calculated	placebo
Adverse effects other than taste disturbance
RCT 3-armed trial	Children aged 12–17 years In review	Adverse effects (other than taste disturbance) with nasal sumatriptan 20 mg with nasal sumatriptan 5 mg with placebo			Not significant
RCT Crossover design	129 children, 94 included in the intention-to-treat analysis In review	Adverse effects (other than taste disturbance) with nasal sumatriptan with placebo	The results of the RCT should be interpreted with caution as it randomised children but assessed results in relation to number of attacks		Not significant