Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Pain
RCT 4-armed trial	850 children aged 12–17 years, 699 (82%) treated for at least one migraine attack In review	Proportion of children who responded (pain intensity was recorded on a 4-point scale, where 0 = no pain and 4 = severe pain) 2 hours 54% with zolmitriptan 10 mg 58% with placebo Absolute numbers not reported	Reported as not significant		Not significant
RCT 4-armed trial	850 children aged 12–17 years, 699 (82%) treated for at least one migraine attack In review	Proportion of children who were pain free (pain intensity was recorded on a 4-point scale, where 0 = no pain and 4 = severe pain) 2 hours 25% with zolmitriptan 10 mg 20% with placebo Absolute numbers not reported	Reported as not significant		Not significant
RCT 3-armed trial	32 children, 29 (90%) of whom were included in the intention-to-treat analysis	Proportion of children with pain relief (pain was measured on a 4-point scale [none, mild, moderate, or severe] and pain relief was defined as no or mild headache after moderate or severe headache) 1 hour 45% with zolmitriptan 7% with placebo Absolute numbers not reported	P <0.01 The RCT made statistical adjustments for related samples when comparing zolmitriptan versus placebo	Effect size not calculated	zolmitriptan
RCT 3-armed trial	32 children, 29 (90%) of whom were included in the intention-to-treat analysis	Proportion of children with pain relief (pain was measured on a 4-point scale [none, mild, moderate, or severe] and pain relief was defined as no or mild headache after moderate or severe headache) 2 hours 62% with zolmitriptan 28% with placebo Absolute numbers not reported	P <0.05 The RCT made statistical adjustments for related samples when comparing zolmitriptan versus placebo	Effect size not calculated	zolmitriptan
RCT 3-armed trial	32 children, 29 (90%) of whom were included in the intention-to-treat analysis	Proportion of children with pain relief (pain was measured on a 4-point scale [none, mild, moderate, or severe] and pain relief was defined as no or mild headache after moderate or severe headache) 4 hours 83% with zolmitriptan 4% with placebo Absolute numbers not reported	P <0.01 The RCT made statistical adjustments for related samples when comparing zolmitriptan versus placebo	Effect size not calculated	zolmitriptan