Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Headache disability
RCT	100 children aged 5–15 years with migraine headache, based on the ICHD-II criteria, and with frequent (at least 1 headache attack per week) or disabling headache (>20 on the PedMIDAS scale)	Headache disability (assessed by PedMIDAS, whereby a score >20 = disabling) at 3 months 23.64 with propranolol 9.26 with topiramate	P = 0.001	Effect size not calculated	topiramate