Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Adverse effects
RCT	100 children aged 5–15 years with migraine headache, based on the ICHD-II criteria, and with frequent ( at least 1 headache attack per week) or disabling headache (>20 on the PedMIDAS scale)	Adverse effects with propranolol with topiramate
RCT	86 children aged 3–15 years with migraine (defined by the 2004 IHS criteria) and >3 headaches per month, or severe disabling/intolerable headache	Adverse effects with propranolol with topiramate