Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Migraine frequency
Systematic review	Children aged 18 years and younger with migraine, tension headache, and mixed headaches 2 RCTs in this analysis	Headaches per month at 3 months with flunarizine with placebo	Mean difference –2.27 95% CI –4.65 to +0.11 P value not reported Reported as a clinically meaningful difference, but sample size in the analysis too small to be statistically significant Heterogeneity: I2 = 85.6% (P value not reported)		Not significant
Systematic review	Children aged 18 years and younger with migraine Data from 1 RCT	Headaches per month at 3 months with flunarizine with placebo	Mean difference –3.52 95% CI –4.91 to –2.13 P value not reported	Effect size not calculated	flunarizine
Migraine duration
Systematic review	48 children aged 18 years or younger with migraine (defined using Vahlquist criteria) Data from 1 RCT	Mean headache duration per attack (hours) at 3 months 2.21 with flunarizine 2.76 with placebo	Standardised mean difference –0.41 95% CI –1.02 to +0.20 Reported as not statistically significant P value not reported		Not significant