Ref (type)	Population	Outcome, Interventions	Results and statistical analysis	Effect size	Favours
Migraine frequency
Systematic review	Children with migraine 2 RCTs in this analysis	Headache frequency per month with topiramate with placebo Absolute results not reported	Mean difference –0.71 95% CI –1.19 to –0.24 P value not reported Topiramate reported as more effective than placebo	Effect size not calculated	topiramate
Systematic review	Children with migraine 2 RCTs in this analysis	Proportion of children with >50% reduction in headaches with topiramate with placebo Absolute results not reported	RR 1.3 95% CI 0.93 to 1.84 Heterogeneity: I2 = 50.4% P values not reported		Not significant
RCT	44 children with migraine In review	Decrease in mean monthly migraine days 4 months 11.9 days with topiramate 5.9 days with placebo	P = 0.02	Effect size not calculated	topiramate
RCT	44 children with migraine In review	Proportion of children with >50% reduction in monthly migraine days 4 months 20/21 (95%) with topiramate 11/21 (52%) with placebo	P = 0.002	Effect size not calculated	topiramate