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. 2015 Jun 5;6:128. doi: 10.3389/fneur.2015.00128

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Copyright © 2015 Ramkisoensing and Meijer.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Influence of environmental conditions on SCN amplitude. Effects of (A) continuous darkness (212), (B) continuous light (212), (C) sleep deprivation (170), and (D) behavioral activity/physical exercise (254) on SCN neuronal activity measured using long-term in vivo recording of the SCN in freely moving mice. In (A–D), the x-axis indicates (circadian) time (in hours), and the y-axis shows the electrical activity of the SCN ensemble (MUA, or multiunit activity) recording. (E) Schematic summary of the effects of continuous darkness, continuous light, sleep deprivation, and behavioral activity (exercise) on SCN neuronal activity. The red and blue areas under the curves represent a decrease or increase, respectively, in the SCN’s rhythm amplitude.