Table 1.
Characteristics of individual studies included in the meta-analysis
| First author, reference | Year | Ethnicity | Gender | Study population | Outcomes |
|---|---|---|---|---|---|
| Aburatani [11] | 1988 | Asian | M/F | Subjects with hyperlipidemia and controls | APOC3, TG, TC, HDL-C |
| Paulweber1 [12] | 1988 | Caucasian | M | Patients with CVD | TG |
| Paulweber2 [12] | 1988 | Caucasian | M | Subjects without CVD | TG |
| Ahn [13] | 1991 | Other | M/F | Random subjects | APOC3, TG, TC |
| Shoulders1 [14] | 1991 | Caucasian | M | Healthy subjects | APOC3 |
| Shoulders2 [14] | 1991 | Caucasian | F | Healthy subjects | APOC3 |
| Ordovas1 [15] | 1991 | Caucasian | M/F | Patients with CVD | TG, TC, HDL-C |
| Ordovas2 [15] | 1991 | Caucasian | M/F | Healthy population | TG, TC, HDL-C |
| Tybjaerg-Hansen1 [16] | 1993 | Caucasian | M | Subjects with CVD | TG, HDL-C |
| Tybjaerg-Hansen2 [16] | 1993 | Caucasian | M | Subjects without CVD | TG, HDL-C |
| Miettinen1 [17] | 1994 | Caucasian | M/F | Subjects with CVD | TG, TC, LDL-C, HDL-C |
| Miettinen2 [17] | 1994 | Caucasian | M/F | Subjects without CVD | TG, TC, LDL-C, HDL-C |
| Rigoli [18] | 1995 | Caucasian | M/F | Patients with type 2 diabetes | TG, TC, LDL-C, HDL-C |
| Bai1 [19] | 1995 | Asian | M/F | Subjects with CVD | APOC3, TG, TC, HDL-C |
| Bai2 [19] | 1995 | Asian | M/F | Subjects without CVD | APOC3, TG, TC, HDL-C |
| Shoulders [20] | 1996 | Caucasian | M/F | Random healthy children | APOC3, TG |
| López-Miranda [21] | 1997 | Caucasian | M | Random healthy youth | TG, TC, LDL-C, HDL-C |
| Kee [22] | 1999 | Caucasian | M | Random subjects | APOC3, TG, TC, LDL-C, HDL-C |
| Dallongeville1 [23] | 2000 | Caucasian | M | Random subjects | APOC3, TG, TC, LDL-C, HDL-C |
| Dallongeville2 [23] | 2000 | Caucasian | F | Random subjects | APOC3, TG, TC, LDL-C, HDL-C |
| Wu [24] | 2000 | Asian | M/F | Random subjects without CVD | APOC3, TG, TC, LDL-C, HDL-C |
| Waterworth1 [25] | 2000 | Caucasian | M/F | Non-smokers | TG |
| Waterworth2 [25] | 2000 | Caucasian | M/F | Exsmokers (cessation for minimum of 1 year) | TG |
| Waterworth3 [25] | 2000 | Caucasian | M/F | Current smokers | TG |
| Russo1 [26] | 2001 | Caucasian | M | Framingham Offspring Study | APOC3, TG, TC, LDL-C, HDL-C |
| Russo2 [26] | 2001 | Caucasian | F | Framingham Offspring Study | APOC3, TG, TC, LDL-C, HDL-C |
| Olivieri [27] | 2002 | Caucasian | M/F | Subjects with or without CVD | APOC3, TG |
| Corella1 [28] | 2002 | Caucasian | M | Random healthy subjects | TG, TC, LDL-C, HDL-C |
| Corella2 [28] | 2002 | Caucasian | F | Random healthy subjects | TG, TC, LDL-C, HDL-C |
| Rodrigo1 [29] | 2002 | Caucasian | M | Patients undergoing kidney transplantation | TG, TC |
| Rodrigo2 [29] | 2002 | Caucasian | F | Patients undergoing kidney transplantation | TG, TC |
| Couillard [30] | 2003 | Caucasian | M | Abdominally obese subjects | APOC3, TG, TC, LDL-C, HDL-C |
| Brown [31] | 2003 | Other | M/F | Random subjects | TG, TC, LDL-C, HDL-C |
| Espino-Montoro [32] | 2003 | Caucasian | M/F | Hypertensive patients | TG, TC, LDL-C, HDL-C |
| Chen [33] | 2004 | Asian | M/F | Patients with type 2 diabetes | APOC3, TG, TC, LDL-C, HDL-C |
| Chhabra1 [34] | 2004 | Asian | M/F | Patients with CVD | TG, TC, LDL-C, HDL-C |
| Chhabra2 [34] | 2004 | Asian | M/F | Subjects without CVD | TG, TC, LDL-C, HDL-C |
| Liu1 [35] | 2004 | Caucasian | M | Subjects with CVD | TG, TC, HDL-C |
| Liu2 [35] | 2004 | Caucasian | M | Subjects without CVD | TG, TC, HDL-C |
| de França1 [36] | 2005 | Other | M | Healthy children | TG, TC, LDL-C, HDL-C |
| de França2 [36] | 2005 | Other | F | Healthy children | TG, TC, LDL-C, HDL-C |
| Arai1 [37] | 2005 | Asian | M | Random subjects | TG, LDL-C, HDL-C |
| Arai2 [37] | 2005 | Asian | F | Random subjects | TG, LDL-C, HDL-C |
| Liu1 [38] | 2005 | Asian | M/F | Patients with CVD | TG, TC, LDL-C, HDL-C |
| Liu2 [38] | 2005 | Asian | M/F | Patients with type 2 diabetes | TG, TC, LDL-C, HDL-C |
| Liu3 [38] | 2005 | Asian | M/F | Subjects without CVD and type 2 diabetes | TG, TC, LDL-C, HDL-C |
| Islam [39] | 2005 | Caucasian | M/F | Random subjects | TG, TC, LDL-C, HDL-C |
| Stancáková [40] | 2006 | Caucasian | M/F | Patients with dyslipidemia of metabolic syndrome | TC, LDL-C, HDL-C |
| Herron [41] | 2006 | Caucasian | M/F | Random subjects | APOC3, TG, LDL-C, HDL-C |
| Huang [42] | 2006 | Asian | M/F | Subjects with hypertriglyceridemia or normal | APOC3, TG |
| Fiegenbaum1 [43] | 2007 | Caucasian | M | Random healthy subjects | TG, HDL-C |
| Fiegenbaum2 [43] | 2007 | Caucasian | F | Random healthy subjects | TG, HDL-C |
| Nieminen [44] | 2007 | Caucasian | M/F | Random youth | TG, TC, LDL-C, HDL-C |
| Parzianello1 [45] | 2008 | Asian | M/F | Subjects with hypertriglyceridemia | TG, TC, LDL-C, HDL-C |
| Parzianello2 [45] | 2008 | Asian | M/F | Subjects free of hypertriglyceridemia | TG, TC, LDL-C, HDL-C |
| Dallongeville [46] | 2008 | Caucasian | M/F | Random subjects | TG, HDL-C |
| Ruiz1 [47] | 2008 | Caucasian | M | Random healthy children | TG, TC, LDL-C, HDL-C |
| Ruiz2 [47] | 2008 | Caucasian | F | Random healthy children | TG, TC, LDL-C, HDL-C |
| Smith1 [48] | 2009 | Caucasian | M/F | Patients with type 2 diabetes | TG, TC, LDL-C, HDL-C |
| Smith2 [48] | 2009 | Caucasian | M/F | Subjects free of type 2 diabetes | TG, TC, LDL-C, HDL-C |
| Yiyang1 [49] | 2010 | Asian | M/F | Random subjects | TG, TC, LDL-C, HDL-C |
| Yiyang2 [49] | 2010 | Asian | M/F | Random subjects | TG, TC, LDL-C, HDL-C |
| Sediri1 [50] | 2011 | Other | M | Males with CVD | TG, TC, LDL-C, HDL-C |
| Sediri2 [50] | 2011 | Other | M | Males without CVD | TG, TC, LDL-C, HDL-C |
| Abd El-Aziz3 [51] | 2011 | Other | M/F | Patients with CVD and controls | TG, TC, LDL-C, HDL-C |
| Bandegi1 [52] | 2011 | Other | M/F | Subjects with primary hyperlipidemia | TG, TC, LDL-C, HDL-C |
| Bandegi2 [52] | 2011 | Other | M/F | Normolipidemic subjects | TG, TC, LDL-C, HDL-C |
CVD: cardiovascular disease, M: male, F: female, TG: triglyceride, TC: total cholesterol, LDL-C: low-density lipoprotein cholesterol, HDL-C: high-density lipoprotein cholesterol.