Table 2.
Meta-analysis of the APOC3 rs5128 polymorphism and plasma APOC3 and lipids association
| Groups or subgroups | Comparisons (n) | Q test P value | SMD (95% CI) | P |
|---|---|---|---|---|
| APOC3 | ||||
| All | 18 | 0.004 | 0.22(0.12, 0.31) | <0.00001 |
| All in HWE | 15 | 0.007 | 0.20(0.09, 0.32) | 0.001 |
| Healthy | 12 | 0.001 | 0.22(0.08, 0.35) | 0.001 |
| Male | 5 | 0.135 | 0.11(−0.05, 0.27) | 0.170 |
| Caucasian | 11 | <0.00001 | 0.26(0.11, 0.40) | 0.001 |
| Asian | 6 | 0.981 | 0.15(0.02, 0.29) | 0.029 |
| TG | ||||
| All | 64 | <0.00001 | 0.33(0.23, 0.44) | <0.00001 |
| All in HWE | 48 | <0.00001 | 0.31(0.20, 0.42) | <0.00001 |
| Male | 19 | 0.411 | 0.14(0.07, 0.21) | <0.00001 |
| Female | 8 | 0.062 | 0.17(0.04, 0.29) | 0.011 |
| Children | 5 | <0.00001 | 0.53(−0.37, 1.44) | 0.249 |
| Caucasian | 38 | <0.00001 | 0.39(0.24, 0.54) | <0.00001 |
| Asian | 17 | 0.302 | 0.18(0.12, 0.25) | < 0.00001 |
| Other | 9 | < 0.00001 | 0.37(0.04, 0.69) | 0.026 |
| Healthy | 39 | < 0.00001 | 0.24(0.13, 0.35) | < 0.00001 |
| CVD | 9 | 0.188 | 0.29(0.16, 0.43) | < 0.00001 |
| TC | ||||
| All | 49 | < 0.00001 | 0.15(0.09, 0.22) | < 0.00001 |
| All in HWE | 41 | 0.06 | 0.12(0.07, 0.18) | < 0.00001 |
| Male | 13 | 0.52 | 0.06(−0.01, 0.14) | 0.105 |
| Female | 6 | 0.23 | 0.20(0.07, 0.33) | 0.002 |
| Children | 4 | 0.062 | 0.30(0.05, 0.55) | 0.021 |
| Caucasian | 26 | 0.08 | 0.11(0.05, 0.18) | 0.001 |
| Asian | 14 | 0.19 | 0.15(0.06, 0.24) | 0.001 |
| Other | 9 | < 0.00001 | 0.25(−0.03, 0.53) | 0.081 |
| Healthy | 39 | 0.53 | 0.10(0.06, 0.14) | < 0.00001 |
| CVD | 7 | 0.46 | 0.15(0.04, 0.26) | 0.008 |
| Type 2 diabetes | 4 | 0.18 | 0.24(0.05, 0.43) | 0.013 |
| LDL-C | ||||
| All | 42 | < 0.00001 | 0.11(0.04, 0.17) | 0.001 |
| All in HWE | 34 | 0.043 | 0.07(0.01, 0.13) | 0.021 |
| Male | 11 | 0.069 | 0.06(−0.10, 0.12) | 0.847 |
| Female | 6 | 0.197 | 0.13(0.02, 0.24) | 0.021 |
| Children | 4 | 0.109 | 0.28(0.05, 0.51) | 0.016 |
| Caucasian | 21 | 0.134 | 0.06(0.00, 0.13) | 0.051 |
| Asian | 13 | 0.262 | 0.09(0.01, 0.16) | 0.021 |
| Other | 8 | < 0.00001 | 0.22(−0.06, 0.50) | 0.119 |
| Healthy | 28 | 0.159 | 0.06(0.01, 0.11) | 0.012 |
| CVD | 4 | 0.115 | 0.07(−0.13, 0.27) | 0.482 |
| Type 2 diabetes | 4 | 0.996 | 0.22(0.08, 0.36) | 0.002 |
| HDL-C | ||||
| All | 54 | 0.314 | −0.03(−0.06, 0.01) | 0.156 |
| All in HWE | 42 | 0.195 | −0.01(−0.06, 0.03) | 0.597 |
| Male | 16 | 0.474 | −0.01(−0.13, 0.00) | 0.062 |
| Female | 7 | 0.663 | −0.03(−0.11, 0.06) | 0.540 |
| Children | 4 | 0.989 | 0.03(−0.13, 0.19) | 0.733 |
| Caucasian | 30 | 0.763 | −0.06(−0.10, −0.02) | 0.007 |
| Asian | 16 | 0.173 | 0.06(−0.02, 0.13) | 0.156 |
| Other | 8 | 0.562 | −0.03(−0.06, 0.01) | 0.536 |
| Healthy | 35 | 0.332 | −0.03(−0.07, 0.011) | 0.160 |
| CVD | 8 | 0.632 | −0.02(−0.13, 0.09) | 0.729 |
| Type 2 diabetes | 4 | 0.656 | 0.01(−0.14, 0.15) | 0.915 |
CVD: cardiovascular disease, TG: triglyceride, TC: total cholesterol, LDL-C: low-density lipoprotein cholesterol, HDL-C: high-density lipoprotein cholesterol.