Table 1.
TEIPP peptide-epitopes defined thus far based on CD8 T-cell recognition.
| Peptide sequence/MHC class I | Source protein | Location in protein | Responsible enzyme | Presented upon | Reference |
|---|---|---|---|---|---|
| MCLRMTAVM H2-Db | Trh4 Q9D6K9 (1) | C-terminal | SPP (2) | TAP deficiency | (53) |
| “mi3 epitope” H2-Kb | Unknown | Unknown | Proteasome | TAP deficiency | (119) |
| FAPLPRLPTL Qa-1b (3) | Acyl carrier protein Q9CR21 | N-terminal | Unknown | TAP deficiency | (91) |
| FYAEATPML Qa-1b | Fam49b “hypothetical protein” NM_144846 | Central | Unknown | ERAAP (4) deficiency | (92) |
| VLLQAGSLHA HLA-A2*0201 | Preprocalcitonin P01258 | Signal sequence | SP (5) and SPP | TAP deficiency | (97) |
(1) UniProtKB database.
(2) SPP is signal peptide peptidase.
(3) Qa-1b is the mouse homolog of HLA-E.
(4) ERAAP is ER-amino-peptidase.
(5) SP is signal peptidase.