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. 2015 Jun 1;8(6):543–551. doi: 10.1242/dmm.020107

Fig. 3.

Fig. 3.

Effects of lysyl oxidase inhibition on body weight evolution, adipocyte size and distribution and total collagen content in epididymal adipose tissue from control and obese rats. (A) Body weight evolution along the study. (B) Adipocyte area of epididymal adipose tissue analysed in haematoxylin-eosin-stained sections from control rats fed a normal chow (CT) and rats fed a high-fat diet (HFD) treated with vehicle or with the inhibitor of LOX activity (β-aminopropionitrile, BAPN, 100 mg/kg/day). (C) Representative microphotographs of sections stained with haematoxylin and eosin and then examined by using light microscopy (magnification 40×). (D) Size distribution of adipocytes from epididymal adipose tissue of the animals described in B. (E) Quantification of collagen volume fraction (CVF) normalised for the number of adipocytes analysed in epididymal adipose tissue sections stained with Picrosirius Red. (F) Representative microphotographs of sections stained with Picrosirius Red that were examined by using light microscopy (magnification 40×). Scale bars: 50 µm. Values are mean±s.d. of six to eight animals. *P<0.05, **P<0.01, ***P<0.001 vs control group. †P<0.05, ††P<0.01 vs HFD group.