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Effect of the L-citrulline on ADMA-induced reduction of O2.− production in PCA. (a) O2.− production was endothelium-dependent. The L-citrulline could not alert the O2.− production in PCA without endothelium. (b) Exposure to ADMA for 24 h significantly elevated O2.− level that was reversed by L-citrulline in PCA with endothelium. Data are shown as mean ± SEM. (**p < 0.01, vs. control group. # p < 0.05, vs. ADMA group. n = 3, one-way ANOVA).
