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. Author manuscript; available in PMC: 2016 Jan 1.
Published in final edited form as: Immunol Rev. 2015 Jan;263(1):279–301. doi: 10.1111/imr.12244

Fig. 1. Chemical structures and inhibitory activity of PPI inhibitors developed for hematology-related protein targets.

Fig. 1

(A) ABT-263 targeting Bcl-2 family of proteins. (B) Small molecule inhibitors of the menin-MLL interaction: MI-2-2 and MIV-6R. (C) Inhibitors of WDR5-MLL interaction: small molecule WDR5-0103 and peptidomimetic MM-401. (D) Small molecule inhibitor of CBFβ-Runx1 interaction: cpd 14. (E) Inhibitors of BET bromodomains: JQ1 and I-BET151. (F) Small molecule inhibitor of BCL6: 79-6.