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. Author manuscript; available in PMC: 2015 Jun 5.
Published in final edited form as: Behav Brain Res. 2014 Jan 7;262:101–108. doi: 10.1016/j.bbr.2013.12.014

Fig. 2.

Fig. 2

Effects of adolescent nicotine exposure on ethanol-induced conditioned place preference (CPP) in adults. Rats were classified as exhibiting HLA or LLA on PND 31 as described, and received injections of either saline (0.9%) or nicotine (0.56 mg free base/kg) once daily for 8 days from PND 35–42. From PND 61–68, rats were trained using 1.0 g/kg ethanol (17%, i.p.) or saline in a biased CPP paradigm, and CPP determined on PND 69. Preference scores were calculated by subtracting the time spent in the initially preferred chamber (paired with saline injection) from the time spent in the initially non-preferred chamber (paired with either saline or ethanol). Bars represent the mean + sem of determinations from 5 rats/group, and significant (p<0.05) differences between groups are noted with an asterisk.