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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Neurogastroenterol Motil. 2014 Oct 19;26(12):1771–1782. doi: 10.1111/nmo.12459

Figure 3.

Figure 3

HM01 prevented acute LD/CD-induced delayed gastric emptying. First, basal gastric emptying in 6-OHDA and control rats was examined without drug treatment. Viscous liquid (1.0 mL) containing acetaminophen (100 mg kg−1) was gavaged to overnight-fasted rats and plasma acetaminophen levels were monitored (A). Gastric emptying assessed as AUCs of plasma acetaminophen levels was comparable between two groups (B). Data are mean ± SEM of 7 and 9 rats for control and 6-OHDA rats, respectively. Next, vehicle or HM01 (3 mg kg−1) was gavaged to overnight-fasted rats 30 min before gavage of LD/CD (20/2 mg kg−1), and 10 min later viscous liquid containing acetaminophen was gavaged to measure gastric emptying (C). Data are mean ± SEM of 7 and 9 rats for control and 6-OHDA rats, respectively. *P < 0.05 Veh+LD/CD vs. basal; †P < 0.05 HM01+LD/CD vs. Veh+LD/CD at each time point of each group.