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. Author manuscript; available in PMC: 2015 Dec 1.
Published in final edited form as: Neurogastroenterol Motil. 2014 Oct 19;26(12):1771–1782. doi: 10.1111/nmo.12459

Figure 4.

Figure 4

Effects of 1-week treatment of HM01 combined with LD/CD on food and water intake, body weight and gastric emptying. Rats received 1-week repeated og administration of vehicle or HM01 (3 mg kg−1) combined with LD/CD (20/2 mg kg−1). (A) Average food intake and (B) water intake during 1-week repeated administration. (C) Body weight changes during 1-week treatment. Data are mean ± SEM of n = 6 in control and n = 9 in 6-OHDA groups. *P < 0.05 vs. each Veh+LD/CD. On Day 8, vehicle or HM01 (3 mg kg−1) was gavaged to overnight-fasted rats 30 min before gavage of LD/CD (20/2 mg kg−1), and 10 min later viscous liquid containing acetaminophen was gavaged to measure gastric emptying (D). Data was analyzed comparing with basal gastric emptying measured earlier in the same animals. *P < 0.05 Veh+LD/CD vs. basal, †P < 0.05 HM01+LD/CD vs. Veh+LD/CD at each time point of each group.