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Pharmacological profile of HM01
| Determination | Values |
|---|---|
| hGHS-R1a binding, Ki | 1.42 ± 0.36 nM |
| hGHS-R1a calcium signaling, EC50 | 1.25 ± 0.15 nM |
| Bioavailability (rat) | 70.6 ± 26.9% |
| Half-life in plasma (rat) | 4.3** ± 1.0 h |
| CNS permeability, Kp brain/plasma (rat) | 0.73 ± 0.14 ( at 2 h) 0.80 ± 0.23 (at 4 h) 0.67* (at 8 h) |
: n = 1
: Half-life calculated after HM01 oral administration
Kp: ratio of brain and plasma concentrations
