Table 1.
Characteristic | Cohort | 1991-1995 | 1996-2000 | 2001-2005 | 2006-2009 | P-value |
---|---|---|---|---|---|---|
N | SWOG | 392 | 406 | 113 | 498 | |
MDA | 102 | 638 | 732 | 470 | ||
Age | SWOG | 64 (17, 89) | 65 (19, 85) | 58 (20, 83) | 49 (19, 60) | <0.001 |
MDA | 58 (18, 83) | 60 (17, 87) | 59 (14, 85) | 56 (18, 88) | <0.001 | |
WBC (×103) | SWOG | 18 (0, 416) | 13 (1, 244) | 10 (1, 370) | 13 (0, 545) | 0.16 |
MDA | 14 (0, 262) | 8 (0, 394) | 7 (0, 433) | 5 (0, 204) | <0.001 | |
Platelets (×103) | SWOG | 56 (3, 537) | 53 (2, 1200) | 49 (5, 1200) | 55 (2, 9300) | 0.39 |
MDA | 59 (5, 1355) | 46 (3, 2292) | 51 (4, 676) | 45 (4, 535) | 0.02 | |
Blood blast % | SWOG | 32 (0, 99) | 30 (0, 99) | 22 (0, 97) | 31 (0, 99) | 0.044 |
MDA | 24 (0, 94) | 20 (0, 99) | 18 (0, 99) | 17 (0, 98) | 0.28 | |
PS 0/1 % | SWOG | 69 | 84 | 81 | 87 | <0.001 |
MDA | 60 | 65 | 80 | 86 | <0.001 | |
De novo AML % | SWOG | 80 | 78 | 85 | 100 | <0.001 |
MDA | 50 | 52 | 45 | 55 | 0.007 | |
TRM % | SWOG | 18 | 13 | 12 | 3 | <0.001 |
MDA | 16 | 14 | 9 | 4 | <0.001 |